Vontz Center for Molecular Studies
University of Cincinnati Medical Center
3125 Eden Avenue
Cincinnati, OH 45267-0521
david [dot] plas [at] uc [dot] edu
One of the major challenges in cancer therapy is to specifically induce cancer cell death while avoiding harm to normal cells in the body. The Plas lab is addressing this challenge by investigating the links between metabolic alterations and cancer cell survival mechanisms. The protein kinase S6K1 regulates cancer cell metabolism of glucose as well as fatty acids. We are investigating the potential of targeted therapeutics that interrupt S6K1 pathway signaling to disrupt cancer cell metabolism, thereby increasing the susceptibility of transformed cells to undergo programmed cell death. In particular, we are exploring metabolism, signaling and survival mechanisms in the context of leukemia, glioblastoma, and breast cancer.